Title: Dahurelmusin A, a hybrid Peptide–Polyketide from Elymus dahuricus infected by the Epichlo?  bromicola endophyte

Author: Song Qiuyan, Yu Haitao, Zhang Xingxu, Nan Zhibiao *, and Gao Kun *

Journal: Organic Letters

Impact Factor:IF₂₀₁₆=6.78(化学一区)

Abstract：One novel hybrid peptide-polyketide, dahurelmusin A (1), was isolated from Elymus dahuricus infected by the Epichloe? bromicola endophyte. Comprehensive spectroscopic analysis revealed that 1 is the first example of hybrid
peptide-polyketide possessing an unprecedented 5-hydroxy-2,2,4,6-tetramethyl-3-oxooctanoic acid moiety. The singlecrystal X-ray diffraction analyses allowed the absolute configuration assignment of this compound. Compound 1also exhibited significant insecticidal activities against Rhopalosiphum padi and Brevicoryne brassicae with LC50 values of 0.092 and 0.251 mM, respectively.

链接： http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03568